Mechanisms of collagen fibril alignment in tendon injury: From tendon regeneration to artificial tendon
نویسندگان
چکیده
منابع مشابه
Collagen fibril bundles: a branching assembly unit in tendon morphogenesis.
The assembly, deposition and organization of collagen fibril bundles and their composite fibrils were studied during morphogenesis of the chick embryo tendon using electron microscopy, serial sections and computer-assisted three-dimensional reconstruction techniques. The 14-day chick embryo is a stage when tendon architecture is being established and rapid changes in the mechanical properties o...
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To date, the cell and molecular mechanisms regulating tendon healing are poorly understood. Here, we establish a novel model of tendon regeneration using neonatal mice and show that neonates heal via formation of a 'neo-tendon' that differentiates along the tendon specific lineage with functional restoration of gait and mechanical properties. In contrast, adults heal via fibrovascular scar, abe...
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Equine tendon injuries have been recognized and treated for centuries. In early American texts, poor conformation was considered a primary risk factor. “Tied-in” at the knees and long, weak, and slender pasterns were thought to predispose the horse to injury because of mechanical disadvantage. Any trait that favored fetlock extension such as low heels and long toes was thought to increase a hor...
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The structure of an ideal scaffold for tendon regeneration must be designed to provide a mechanical, structural and chemotactic microenvironment for native cellular activity to synthesize functional (i.e. load bearing) tissue. Collagen fibre scaffolds for this application have shown some promise to date, although the microstructural control required to mimic the native tendon environment has ye...
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Hand trauma arising from postoperative acute or chronic tendon injuries leads to delayed union and is one of the greatest challenges in clinical practice. The present study hypothesized that an extracellular matrix hydrogel made from tendons can promote tendon healing and improve tissue regeneration. To verify this, 36 Wistar rats were subjected to bilateral full-thickness injury of their Achil...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2011
ISSN: 0736-0266
DOI: 10.1002/jor.21460